American Airlines has dropped fares to $601 for San Francisco to Sao Paulo GRU Brazil, available for most departure dates between August and mid-December 2015. This is a low fare for a high mileage route.
American Airlines San Francisco – Miami – Sao Paulo – Los Angeles – SFO
$600.84 September 9 – September 13, 2015
Routing kind of depends on your flying preferences. The total distance is about the same when flying SFO-GRU via Miami or SFO-GRU via LAX. The main factor is whether you want to knock out the trip with one long 6,150 LAX-GRU segment or break the trip up into two smaller segments with SFO-MIA at 2,585 miles and MIA-GRU at 4,072 miles.
When flying economy class, I kind of prefer the shorter segments rather than suffering through a 13-hour economy class long haul flight.
Los Angeles fares are priced about $120 to $200 more on American Airlines for this route.